- Saturday LOCKN’ Delivers Mega Acts My Morning Jacket, Tedeschi Trucks, Phil Lesh & A Ton of Friends
Load remaining images Lockn’ Festival continued with another full day of music on Saturday. The morning started off with Keller Williams’ Grateful Grass. Jeremy Garrett, of the Infamous Stringdusters, provided a mean fiddle to the morning set. He had that rosin screaming as it danced across the well played strings. Andy Falco pounded out the chords on the guitar, as the group sang the lyrics with a smile. It was a perfect way to get the venue to wake up on a high note. The main stage opened a half hour later due to the last minute cancellation of Brandi Carlile, as the first act was pushed up to 12:30. Opening main stage was the first of this year’s two Rockn’ to Lockn’ winners, DJ Williams Projekt. Talk about a funked out powerhouse. This group was heavy on the bass and back brass line. Every tune was crammed with nuggets of intense beats. They were joined early on by Samantha Reed for a performance of The Doors’ “Light My Fire.” They had a strong, positive reception from the crowd. Expect more from this band down the road.Moon Taxi came out balls to the wall. Guitarist, Trevor Terndrup, was full of energy and jumped on a speaker to perform early on. They wasted no time getting down and dirty in the early afternoon. They were charged up and on full blast. “Year Zero” was a ripper of a jam. The song just took off and had a mind of its own. Midway through their set, they took the audience on a crazy musical journey that built the hell up before cooling down and heading into blast off mode. These guys raged their set non-stop. A little jazzy key melody eased its way in before building the vibes to full on extreme mode back into “Cabaret.” “Mercury” splashed into the set list and how appropriate this song was for the heat baking the venue. They casually strolled into “All Along The Watchtower” before shredding the hell out of the song. Keyboardist, Wes Bailey, went ape all over the ivories and took no prisoners by shredding the tune into a thousand pieces. They closed their set with “Morocco”, followed by fan favorite, “All Day All Night.” The crowd joined in towards the end of the song to bring it home. Talk about an incredibly steamy closing song for their set. If you’ve never heard Moon Taxi, do yourself a favor and check them out.As the last notes were being dropped from Moon Taxi, the stage rotated right into the first notes of Twiddle. Keyboardist, Ryan Dempsey, enjoyed the rotation standing on his chair with toes just barely touching his keys. These guys were ready to go. An extra microphone set up hinted at a surprise guest to join in. Slight technical difficulties made the stage crew quickly act to fix the sound situation with guitarist and lead singer, Mihali Savoulidi‘s microphone. Once the situation was remedied, they went into an extensive jam that curved around tones bordering on psychedelic vibes. After dropping sick tunes to start their set, Keller Williams joined in to perform his song “Best Feeling.” It got super funky, down and dirty as they rolled into it. Michael Jackson‘s “Smooth Criminal” became an improvisational work of art. Rolling from reggae funk to down and dirty ripping jams, this band instantly gained new fans from their first set of the festival. They will be performing once again on Sunday afternoon.The stage rotated to bring out the funkiest of grooves in the afternoon. Galactic, with Lee Oskar, rolled out and instantly went right into some tasty deep funk. Forget about sitting on your ass, Stanton Moore is only one of the best drummers out there and pulls the beats out of clouds of energy, setting the grooves on fire. The horns just blew the beats out of the water and exploded in an endless jam that went for miles. The crowd was already sweating but their tunes busted the seams, drenching people in energy they were pouring out. At one point, Moore used his tambourine to help pull out one of the most incredible drum solos. He would tap it and slide it along both the cymbals and drum heads, while using a drum stick with the other hand. He then switched up to using drum brushes before going back into full use of his sticks. One of his drums fell over mid solo, but stage crew was quick to respond and get his set corrected. Erica Falls whipped out one seriously incredible vocal performance when she joined the group on stage. Her vocal control was simply stunning, and her voice an absolute pleasure to drink in the ears. Lee Oskar, the harmonica master himself, was tremendous on his harps. Wow. Hands down one of the hottest performances of Lockn’ so far.Hard Working Americans came around for the crowd next. They grabbed the set by the balls and unleashed a fury of pounding tunes throughout. Guitarists, Neal Casal, and Jesse Aycock gingerly strummed their way through each tune, having the audience think it may be a light song then, without even realizing, the melodies would become fully charged and rock out with wicked intensity. Todd Snider’s growly vocals added to the dynamite group, and perfectly matched the tone of the instruments. Raw, rough, rock and roll, hands down.Phil Lesh and Friends went on later than scheduled, keeping everyone on their toes as to when the set would begin. Lesh was joined by Jon Fishman and Page McConnell of Phish, Anders Osborne, Joe Russo, and the Infamous Stringdusters. The packed stage of musicians opened the show with “Scarlet Begonias.” The mix of fiddle and bluegrass tones really added a flair never heard with Phil & Friends before. Russo and Fishman pulled out a double duty drum solo early on in the set, however the crew was still getting the sound dialed in.Watch full set video, courtesy of Tom Rowles.After a brief moment of sound correction, “Dire Wolf” popped its head, with McConnell’s gentle keys shining through. This version gave the feel of being in a dusty bar in the old west during the gold rush. “Uncle John’s Band” got the whole place dancing and joining in song. The field was jam packed and the energy was top notch. With so many musicians on stage, it was hard to know where to look first. They took the tune on a quick paced ride around the notes, creating a magical journey.As if there weren’t enough musicians on stage, Derek Trucks and Susan Tedeschi joined the group making for one very packed stage. The super group busted out “Mr. Charlie,” as Tedeschi took the lead on vocals before taking “Sugaree” on a breezy trip through the song. Trucks does what Trucks does best and made the tune sound seamless as he went into a remarkable slide guitar jam. The fiddle in the background added touches of beauty throughout.Osborne sat out for the few songs while the power couple joined, but once they got off stage, he joined back in. The crowd was going nuts when they slammed into “Shakedown Street.” Osborne was visibly having a blast on stage as he danced around, all while keeping a giant smile on his face. “Terrapin Station,” for the finish, was absolutely insane. What happened on stage was tearjerkingly good. So goddamn good. An absolute top fan favorite, the venue could not believe they were closing with such a magical tune. The band bowed and the crowd deafeningly cheered to the super group that just blew everyone away. Tedeschi Trucks Band came up next, continuing the intense evening of sick musical acts. Their set was crammed with high energy tunes. Tedeschi belted out her powerful vocals to “The Letter,” followed by “Laugh About It,” featuring Trucks’ cutting loose and tearing up the strings on his guitar. They slowly slid into “Within You Without You,” building it up with mystical tones only to roll into a solid, drum heavy beat.The hot set continued with a heavy brass “Just As Strange,” which featured a fast paced soulful vibe. Kofi Burbridge busted out the flute, adding a delicate tone throughout the tight melody. Trucks was sweating his ass off in the heat, as he dripped all over his guitar. The flawless build up of energy that is plucked from the musical heavens, and spills out of his strings, is unbelievably intense. Then he brings the energy down to a trickle without even trying. The man is a guitar genius.Stream the full audio of the set below, courtesy of taper opsopcopolis.My Morning Jacket headlined for the evening on the main stage. The show started off on a high note with “Victory Dance.” The band wanted to make sure the venue was heating up again, as cooler air was finally rolling in. “Off The Record” had the crowd shouting the lyrics to the band. Guitarist and frontman Jim James really tore into the vibe and his vocals amped up the energy for the evening. Burt Bacharach’s song “What the World Needs Now Is Love” was made into an entirely new version of jam awesome. The packed venue was singing along. Bassist, Tom Blankenship, looked seriously dapper in his vest and tie throughout the evening. “State of The Art (A.E.I.O.U.)” was overflowing at the seams with energy, screaming to be unleashed. The build up was calm and smooth, with keyboardist Bo Kester, starting out on piano, followed by an intro of all instruments one at a time. The energy built and built, until the song went on blast off into the sky. It was insane. Their set also included covers of some of the greatest artists this world has recently lost. Prince’s “Purple Rain” and David Bowie’s “Rebel Rebel” honored these two legends appropriately. “One Big Holiday” closed the killer set and had the venue going insane! For those who had never seen My Morning Jacket, they were blown away. One of the, if not THE, hottest set of the festival so far.Stream the full audio of the set below, courtesy of taper opsopcopolis.Following the end of the evening on the main stage, Super VIP attendees were treated to an intimate Hard Working Americans show. The set began with a rocking, in your face “Opening Statement,” an extensive jam that turned into another dimension with trippy vibes floating around the waves of notes. Within the musical journey, Phil Lesh and Phish’s Mike Gordon joined Widespread Panic’s Dave Schools. A golden trifecta of bass players. Bass bombs and deep tones reverberated throughout the floor, and the crowd, could feel every note being dropped. Susan Tedeschi joined in for a performance of “He’s Gone.” Stuff of legends happened last night. Late night on the Blue Ridge Bowl featured Lettuce. They provided super trippy melodies for the late night crowd as they played until about 3:30 in the morning. Out in the Woods Stage, Khruangbing, followed by a second night of “Jazz & Woods,” featuring DJ Logic, filled the forest with nuggets of crisp tones and late night vibes. Saturday was absolutely nuts with the mega acts that performed. Let’s see what the fourth, and final day has in store. Stay tuned!For more information on the Lockn’ Festival, please visit their official website.Words by Sarah Bourque. Follow on Twitter.Photographs by Sam Shinault Photography.
- Seven recognized for high-risk, high-reward research
Seven Harvard scientists are among the 89 researchers who have been selected to receive grants through the National Institutes of Health’s High-Risk, High-Reward Research program, which funds innovative research designed to address major challenges in biomedical science.Amy Wagers, the Forst Family Professor of Stem Cell and Regenerative Biology and co-chair of the Department of Stem Cell and Regenerative Biology, and Peng Yin, professor of systems biology at Harvard Medical School (HMS), will receive Pioneer Awards; Justin Kim, assistant professor of biological chemistry and molecular pharmacology at HMS, and Po-Ru Loh, assistant professor of medicine there, will receive New Innovator Awards; Richard Lee, professor of stem cell and regenerative biology at Harvard and professor of medicine at HMS, and Norbert Perrimon, James Stillman Professor of Developmental Biology, also at HMS, will receive Transformative Research Awards; and Sergey Ovchinnikov, John Harvard Distinguished Science Fellow, will receive an Early Independence Award.“This program supports exceptionally innovative researchers who have the potential to transform the biomedical field,” said NIH Director Francis S. Collins. “I am confident this new cohort will revolutionize our approaches to biomedical research through their groundbreaking work.”Amy Wagers seeks to change the way we repair our tissues after an injury.Her research reveals how changes in stem cell activity impact tissue maintenance and repair throughout life and explores how these cells may be harnessed for regenerative medicine.Wagers’ substantial contributions to science, published in more than 150 primary research and review articles, have brought to light novel regulators (both intrinsic and extrinsic) of stem cell activity in injury repair, degenerative disease, and malignancy, and highlighted key roles for specific blood-borne mediators, cellular niches, inflammatory and metabolic cues in coordinating the functions of stem cells and their progeny throughout the body.She has also established groundbreaking methods for manipulating stem cell genomes in situ — work that opens new avenues of research and new possibilities for treating congenital and age-related diseases.In addition to her work at the Harvard Stem Cell Institute, Wagers is a senior investigator in the section on islet cell and regenerative biology at the Joslin Diabetes Center and a member of the Paul F. Glenn Center for the Biology of Aging at HMS.Peng Yin is a co-leader of the Wyss Institute’s Molecular Robotics Initiative. His research focuses on DNA and RNA — the molecules otherwise known to encode all cells’ information and pass it from one generation to the next — as a synthetic material to construct, manipulate, and visualize predesigned structures or naturally occurring biomolecules at the nanoscale.The development and improvement of next-generation sequencing methods has enabled researchers to analyze DNA and RNA in cells and tissues with unprecedented sensitivity, and on a massively parallel scale. This has led to new diagnostics and therapies, as well as a new understanding of many biological processes.However, the same level of sensitivity and throughput has not yet been achieved for cells’ proteomes, the full complement of proteins resulting from the specific gene-expression programs that determine their identities and functions. As proteins levels and activities are intricately regulated, being able to take a high-resolution snapshot of cells’ proteomes could ultimately allow better predictions of the states cells are in, provide new insights into their inner molecular workings, and reveal more accurate biomarkers and useful therapeutic targets for diseases.To do that, Yin’s group developed a DNA nanotechnology-based approach, called DNA-PAINT, that is able to visualize single molecules with nanoscale resolution. The system is capable of multiplexed analyses of many molecules, quantifying actual numbers of proteins at a specific location, and visualizing molecular-scale features packed in dense clusters. Yin’s team will harness the sum of these features to develop a method that is able to fingerprint single proteins in cells, complementing next-generation DNA and RNA sequencing to provide a more complete picture of cells’ identities and functions.“I am honored to have been selected for this prestigious award,” said Yin. “With its support, we will leverage our DNA-PAINT super-resolution imaging technology to engineer a ‘single-molecule fingerprinting’ method that can be applied with high throughput to cells’ proteomes. Our work embodies the spirit of the NIH’s commitment to high-risk, high-reward research and ultimately could advance many research areas.”Justin Kim is an assistant professor in the Department of Cancer Biology at Dana-Farber Cancer Institute in addition to his position at HMS, where his research group focuses on the development of new chemical technologies for the discovery and modulation of protein-protein interactions.Kim received his A.B. in chemistry and physics at Harvard University. His Ph.D. work with Mohammad Movassaghi at Massachusetts Institute of Technology (MIT) was directed toward chemical synthesis of bioactive complex natural products, and his postdoctoral research with Carolyn Bertozzi at University of California, Berkeley, and Stanford University focused on the development of biologically compatible chemical reactions.Po-Ru Loh is an assistant professor of medicine in the Division of Genetics and Center for Data Sciences at Brigham and Women’s Hospital, and an associate member of the Broad Institute.He earned his B.S. in mathematics from the California Institute of Technology and Ph.D. in applied mathematics from MIT, where he worked with Professor Bonnie Berger on algorithms for analysis of large genomic data sets.Loh further refined his focus to statistical genetics during a postdoctoral fellowship with Professor Alkes Price at the Harvard T.H. Chan School of Public Health, developing fast statistical algorithms for genome-wide association analysis and haplotype phasing.His research group is now applying these methods to investigate mosaic chromosomal alterations in DNA from blood and bulk tissue while continuing to develop innovative methods for other large-scale genetic data analyses.In addition to the New Innovator Award, his lab is supported by a Burroughs Wellcome Fund Career Award at the Scientific Interface, a Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty, and a Broad Institute Next Generation Fund award.Richard Lee will use the funding from the Transformative Research Award to establish a new research program in collaboration with Peter Dedon, a renowned biochemistry professor at MIT.“I’m extremely excited about this project, as it is work I’ve been thinking about for many years,” Lee said. “We proposed to NIH that there may be some unique molecules within DNA that accumulate with age. That idea has been around for decades, but the mass spectrometry and biochemical technology to search for new DNA molecules have been improving rapidly.”That search will begin in the organ Lee, a cardiologist, called his favorite — the heart — before moving on to search for new DNA molecules in aging brain tissue.“It’s really exciting to do one of these High-Risk, High-Reward projects,” Lee said. “NIH is sometimes criticized for being conservative, but they are willing to take some big chances. I hope we will be among the investigators who deliver.”Norbert Perrimon is an investigator of the Howard Hughes Medical Institute, and an associate member of the Broad Institute.He is a geneticist recognized for his work in signal transduction and the development of functional genomics methods, and is known particularly for the characterization of canonical signaling pathways and the development of methods, such as the FLP-FRT dominant female sterile technique to generate germline mosaics, the GAL4-UAS method to control gene expression both spatially and temporally, and high-throughput RNAi screening.He received a doctorate from the University of Paris in 1983, and has been on the faculty of HMS since 1986. He received the George W. Beadle Medal from the Genetics Society of America in 2004. He has been elected to the American Academy of Arts and Sciences, American Association for the Advancement of Science, EMBO, and National Academy of Sciences.Sergey Ovchinnikov received his B.S. in micro/molecular biology from Portland State University and Ph.D. in molecular and cellular biology from the University of Washington, Seattle.Working in the lab of David Baker, Ovchinnikov investigated algorithms for protein structure determination using evolutionary information. His lab is interesting in developing a unified statistical model of protein evolution to better understand phylogenetics, protein folding, origins of life/multicellularity, and to mine metagenomic “dark matter” sequences to discover new protein families, functions, and protein-protein interactions.The NIH issued 10 Pioneer Awards, 58 New Innovator Awards, 10 Transformative Research Awards, and 11 Early Independence Awards for 2018. The awards total approximately $282 million over five years, pending available funds. Funding for the awards comes from the NIH Common Fund and other Office of the Director appropriations; the National Cancer Institute; the National Center for Complementary and Integrative Health; the National Institute of Allergy and Infectious Diseases; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Institute of General Medical Sciences; the National Institute of Mental Health; and the Office of Research Infrastructure Programs.