Dopapod spent their New Year with friends Aqueous and Consider the Source at the beautiful Madison Theater in Covington, KY. It was a glorious two-night celebration that saw the up-and-comers rock their hardest from 2016 to 2017. Of the many highlights was Dopapod’s cover of “Lateralus” by Tool. With Tool now officially playing at least two dates in 2017, the cover feels more appropriate now than ever.With Eli Winderman singing the parts of Maynard James Keenan, Rob Compa playing the rock-heavy licks of Adam Jones, Chuck Jones thumping hard on bass, and Neal “Fro” Evans holding it down on drums, Dopapod did Tool justice in this amazing cover.Watch Dopapod play “Lateralus” by Tool, courtesy of the great MK Devo:
Over the past few years, researchers led by George Church have made important strides toward engineering the genomes of pigs to make their cells compatible with the human body. So many think that it’s possible that, with the help of CRISPR technology, a healthy heart for a patient in desperate need might one day come from a pig.“It’s relatively feasible to change one gene in a pig, but to change many dozens — which is quite clear is the minimum here — benefits from CRISPR,” an acronym for clustered regularly interspaced short palindromic repeats, said Church, the Robert Winthrop Professor of Genetics at Harvard Medical School (HMS) and a core faculty member of Harvard’s Wyss Institute for Biologically Inspired Engineering. Xenotransplantation is “one of few” big challenges (along with gene drives and de-extinction, he said) “that really requires the ‘oomph’ of CRISPR.” George Church’s scientific drive Beam Therapeutics receives Harvard license Behold the mammoth (maybe) Genetic engineering may undercut human diseases, but also could help restore extinct species, researcher says Related Related Firm will use new base editing technology to make precision genetic medicines The prospect of using living, nonhuman organs, and concerns over the infectiousness of pathogens either present in the tissues or possibly formed in combination with human genetic material, have prompted the Food and Drug Administration to issue detailed guidance on xenotransplantation research and development since the mid-1990s. In pigs, a primary concern has been that porcine endogenous retroviruses (PERVs), strands of potentially pathogenic DNA in the animals’ genomes, might infect human patients and eventually cause disease.That’s where the Church lab’s CRISPR expertise has enabled significant advances. In 2015, the lab published important results in the journal Science, successfully demonstrating the use of genome engineering to eliminate all 62 PERVs in porcine cells. Science later called it “the most widespread CRISPR editing feat to date.”In 2017, with collaborators at Harvard, other universities, and eGenesis, Church and Yang went further. Publishing again in Science, they first confirmed earlier researchers’ fears: Porcine cells can, in fact, transmit PERVs into human cells, and those human cells can pass them on to other, unexposed human cells. (It is still unknown under what circumstances those PERVs might cause disease.) In the same paper, they corrected the problem, announcing the embryogenesis and birth of 37 PERV-free pigs.“Taken together, those innovations were stunning,” said Vivian Berlin, director of business development in OTD, who manages the commercialization strategy for much of Harvard’s intellectual property in the life sciences. “That was the foundation they needed, to convince both the scientific community and the investment community that xenotransplantation might become a reality.”“After hundreds of tests, this was a critical milestone for eGenesis — and the entire field — and represented a key step toward safe organ transplantation from pigs,” said Julie Sunderland, interim CEO of eGenesis. “Building on this study, we hope to continue to advance the science and potential of making xenotransplantation a safe and routine medical procedure.” To facilitate the development of safe and effective cells, tissues, and organs for future medical transplantation into human patients, Harvard’s Office of Technology Development has granted a technology license to the Cambridge biotech startup eGenesis.Co-founded by Church and former HMS doctoral student Luhan Yang in 2015, eGenesis announced last year that it had raised $38 million to advance its research and development work. At least eight former members of the Church lab — interns, doctoral students, postdocs, and visiting researchers — have continued their scientific careers as employees there.“The Church Lab is well known for its relentless pursuit of scientific achievements so ambitious they seem improbable — and, indeed, [for] its track record of success,” said Isaac Kohlberg, Harvard’s chief technology development officer and senior associate provost. “George deserves recognition too for his ability to inspire passion and cultivate a strong entrepreneurial drive among his talented research team.”The license from Harvard OTD covers a powerful set of genome-engineering technologies developed at HMS and the Wyss Institute, including access to foundational intellectual property relating to the Church Lab’s 2012 breakthrough use of CRISPR, led by Yang and Prashant Mali, to edit the genome of human cells. Subsequent innovations that enabled efficient and accurate editing of numerous genes simultaneously are also included. The license is exclusive to eGenesis but limited to the field of xenotransplantation.Could these technologies help bring life-saving tissues and organs to patients in need? The U.S. Department of Health and Human Services’ Organ Procurement and Transplantation Network tracks the statistics. About 114,000 people in the United States are on a waitlist for organ transplants. In the general population, only three in 1,000 people die in a way that would enable their organs to be donated — and then only if they are registered donors. Meanwhile, every day, 20 people on that waitlist die waiting. It’s not, however, the end of the story: An immunological challenge remains, which eGenesis will need to address. The potential for a patient’s body to outright reject transplanted tissue has stymied many previous attempts at xenotransplantation. Church said numerous genetic changes must be achieved to make porcine organs fully compatible with human patients. Among these are edits to several immune functions, coagulation functions, complements, and sugars, as well as the PERVs.“Trying the straight transplant failed almost immediately, within hours, because there’s a huge mismatch in the carbohydrates on the surface of the cells, in particular alpha-1-3-galactose, and so that was a showstopper,” Church explained. “When you delete that gene, which you can do with conventional methods, you still get pretty fast rejection, because there are a lot of other aspects that are incompatible. You have to take care of each of them, and not all of them are just about removing things — some of them you have to humanize. There’s a great deal of subtlety involved so that you get normal pig embryogenesis but not rejection.“Putting it all together into one package is challenging,” he concluded.In short, it’s the next big challenge for CRISPR. ‘If you’re not failing, you’re probably not trying as hard as you could be’ Related
Each and every one of you is currently in a pivotal moment.You just might not know it.Is your business languishing in the face of an unprecedented level of challenge from a particularly fierce competitor? Are you being forced to continually do more with less, pushing you beyond the brink of effectiveness? Perhaps friends and family are quietly suffering because you are simply working too much, or you are not present enough when you are with them.Whatever the circumstance you find yourself in, you may well be in a pivotal moment; you just have to recognize it and decide it’s time to take control of the kind of legacy you leave. It may be time to envision a greater legacy, and then get after it with such energy that it recasts the challenges you face and expands the impact of your future moments in meaningful ways.Here’s how.Introducing The Five Footprints of Legacy – the ways we tend to leave legacies behind at work and in life. Get to work on making such imprints, even a few, each day and enjoy the daily doses of meaning that go along with those efforts. continue reading » 3SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
Patricia Henricksen was born in the living room of this house at 86 Johnston St Southport and lived there for most of her life. Picture Glenn HampsonThey were reluctant to knock the existing house down but Ms Henricksen’s death earlier this month halted any thought of demolition.Mr Elliss said they have decided to offer the one-bedroom, one-bathroom home to anyone who will love it as much Ms Henricksen did.“The idea was to do a development there because it’s such a good location,” Mr Elliss, who works as a real estate agent at Harcourts Broadbeach Mermaid Waters, said.More from news02:37International architect Desmond Brooks selling luxury beach villa17 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago“Since the time that I bought it, I’ve really started to like the character of the house.”He said it would cost between $15,000 and $18,000 to move the home. The one-bedroom, one-bathroom home was built in the 1930s.After cleaning it out and staying the night on occasion, Mr Elliss said he had grown to admire the home.“She left a lot of photos and things like that that I’ve actually found in the cupboard,”he said.Mr Elliss has got to know Ms Henricksen’s family well, even sending old photos to her niece in Melbourne, and has let relatives stay in the house and neighbours use it for a memorial.“I have obviously thought about (knocking it down) but it would be a real shame,” Mr Elliss said. Real estate agent Michael Elliss bought the house and is developing the land. Picture Glenn HampsonA SOUTHPORT home etched in the Gold Coast’s history is being offered up for free – but there’s a catch.The land is not included in the deal and the new owners must pay to relocate the 1930s brick and weatherboard house.The property at 86 Johnston St was home to Patricia Henricksen from the day she was born in the living room in 1935 until it sold at auction last yearMichael Elliss and Cameron Reed of MCM Property Developments snapped it up for $880,000 with plans to build a three-storey unit block. Patricia Henricksen in her living room last year before the house sold. Picture Glenn Hampson“It would be really nice for someone to take it rather than me demolish it, which would be hard to watch.“It’s a good opportunity for someone that wants a bit of extra income or they need somewhere for their parents to live.“The clock is ticking – if no one takes it in the next two to three months then it will just have to come down unfortunately.”
The tracking error cannot be higher than 2% for either mandate.The pension fund has not yet defined a benchmark for the active allocation, but it should have a bias towards mid-cap companies.Investments under the passive mandate should track one of five specified SIX Swiss Exchange indices.The allocations will be housed in an existing ‘umbrella’ fund structure known as an Effektenfond.Interested parties should have at least CHF750m of assets under management for Swiss equities, and CHF1bn as a firm. They should have a track record of at least five years, but track records of more than 10 years are preferred.Applicants should state their performance, gross of fees, to 31 October. The deadline for submissions is 10 December, 5pm UK time, for both mandates. The IPE news team is unable to answer any further questions about IPE Quest, Discovery, or Innovation tender notices to protect the interests of clients conducting the search. To obtain information directly from IPE Quest, please contact Jayna Vishram on +44 (0) 20 3465 9330 or email [email protected] A Swiss pension fund has tendered active and passive domestic equity mandates for a total initial commitment CHF60m (€53m) via IPE Quest.According to searches QN-2494 and QN-2495, managers should expect inflows of around CHF60m until 2022 and an additional CHF80m until 2024.Daily liquidity is needed. Individual holdings of the subfunds have to be capped at 10%. An exclusion list based on environmental, social and corporate governance criteria must be respected.
Press Association The 6ft 8in Ivory Coast international has signed on loan from Monaco, whom he only joined early in the month from Anzhi Makhachkala for a reported £16million. Traore rejected West Ham, who had already obtained a work permit for the striker, for Martinez’s purer footballing principals and the Toffees boss insists they will not change even with the biggest of big front men up top. Romelu Lukaku’s ankle injury, likely to keep him out for several weeks, means there is a void at centre-forward following the sale of Nikica Jelavic to Hull but Traore is still at least 10 days away from full fitness after a hamstring problem. It means either Kevin Mirallas and Steven Naismith will be asked to fill in during the interim but Traore’s anticipated inclusion will not prompt a change of tactics for Martinez. “What we don’t want is to rush Lacina and then he breaks down and we can’t have him for the whole season,” said the Spaniard. “His size will give you the wrong impression of the way he is as a footballer. “He is technically very gifted, he has a real understanding of the space and combination play around him and is really quick with his penetrating runs, he is a real athlete. “All those aspects make us a little bit different because we haven’t got that sort of player with that presence and height. “But we will never change the way we are as a team; our footballing concepts are really clear but the personnel changes bring little tricks and different aspects of our attacking play. “Romelu has been very influential and you don’t have many opportunities to replace him on a like-for-like basis but the flexibility and different combinations and partnerships we have in the final third are exciting. Everton manager Roberto Martinez may have signed one of the tallest players in European football but he insists Lacina Traore’s giant stature reflects the club’s ambition and not a change in style. “We have options up front; Romelu has been in outstanding form and has been leading the line and having the opportunity but we have other players who have been showing good signs and are desperate to help the team and that is what we need. “I am happy we can do different things to still be a good force going forward.” Traore knows he needs game time in order to be in the best shape to secure a place in Ivory Coast’s World Cup squad this summer. He believes a spell working under Martinez can assist him in that, which is why he opted for Everton over West Ham who were first in line and had already secured a work permit before the Merseysiders joined the race for his services. “I looked at the styles of play of the two teams we are talking about and the way in which Everton play is more of a passing side and that style suited my technical ability,” said the 23-year-old. “Also I looked at where they were in the league and they (Everton) were quite well off for points in the league so I think with that sort of emphasis on skill and the passing game I am hoping I can settle in as quickly as possible with my style of play. “I am pleased I have made this choice and I am standing by my choice of this club. “It was a bit of a surprise (Monaco immediately loaning him out) and something I had not thought of but it was a proposition the club came up with to send me to get more experience and improve as a player. “I want to be able to be performing at my absolute top level if I can and I am aware at the back of my mind the World Cup is looming.”
“For myself and those close to me it would be incredible but also for the bigger picture – the fans and the entire country. “There have been quiet moments when my mind has wandered but there is a lot of football to be played yet. “One thing’s for sure, Friday could be a huge step for us.” McAuley’s central-defensive partner in Torshavn is likely to be his new club colleague after Jonny Evans ended his long association with Manchester United to join the Baggies last week. Although Evans has not featured in this campaign after being frozen out at Old Trafford, McAuley anticipates him having no problems if called upon. “Jonny Evans was in a difficult situation when he was at Manchester United and not playing many games,” said McAuley. “But that has changed now and I am delighted he has joined my club. “He hasn’t been involved at the club yet but from watching him in training in the past few days with Northern Ireland, he’s looked like himself. He’s been sharp, on the front foot and he will have no problems whatsoever.” Michael O’Neill’s men head into a double header with the Faroes and Hungary well poised to reach the finals of a major tournament for the first time since the 1986 World Cup. They lie in second place in Group F, one point behind Romania and two ahead of Hungary, with just four games remaining. Monday’s meeting with the Hungarians in Belfast has been billed as a monumental clash to determine Northern Ireland’s qualifying fate, but McAuley has always highlighted Friday’s trip to the Faroe Islands as an important contest in the race to reach France next summer. “I’ve always thought this game was pivotal in this campaign,” said the West Brom defender. “After we won the Finland game everyone said the Romania game (that Northern Ireland drew) was must-win. In many ways that looked after itself but I always looked at this one because of the timing of the game too. “We have six points up for grabs and if we are unbeaten in those two games and hopefully win both, we will take a massive stride to the Euros – and of course there is a chance that two wins would actually see us qualify.” McAuley concedes his thoughts have drifted to what it would be like to represent his country at a major international tournament, something generations of Northern Ireland players have never experienced. The 35-year-old has 51 caps to his credit and has been a Barclays Premier League regular over the past four seasons at The Hawthorns but admits it would be special to make history for Northern Ireland. “You can’t not think about what it would be like to qualify,” he admitted. “I’d love to be in the squad to qualify, for selfish and personal reasons – like having my wife and children see me play at a major tournament; it really keeps me focused. Press Association Gareth McAuley believes Northern Ireland’s trip to the Faroe Islands should be viewed as the “pivotal” point of their Euro 2016 qualifying campaign.
Abdulrahman Bashir and Emeka Nwabulu have been named among the players to vie for the June edition of the Nigeria Professional Football League (NPFL) – League Bloggers Awards (LBA).The two players put in very important contributions for their clubs in June. Bashir scored three times for Nasarawa United while Nwabulu kept four clean sheets in five appearances for Wikki Tourists.Bashir has come good this season for Nasarawa United, scoring 11 league goals, after struggling at Enyimba and Lobi Stars since he left ABS FC, the club where he made his name.However, Bashir and Nwabulu will have to contend with the pair of El-Kanemi Warriors teenage winger Hussaini Bata and Shedrack Oghali of Warri Wolves for the player’s award in June.Oghali’s return for Wolves in the month under review saw him help the Warri club get a point at Kano Pillars in a 2-2 draw in which he scored both goals. Before then, he netted the equaliser that helped Wolves avoid defeat at home in a 2-2 draw with Heartland having gone two goals down.Bata scored three important goals at home for his team against Enugu Rangers, Warri Wolves and Abia Warriors to earn himself a place among the NPFL-LBA shortlists.Four coaches – Gbenga Ogunbote (3SC), Abdu Maikaba (Wikki Tourists), Solomon Ogbeide (Sunshine Stars) and Kabiru Dogo (Nasarawa United) – are the men in line for the manager’s award for June.Ogbeide is the only man to have guided his side to an unbeaten streak in June in the NPFL this season. His team, Sunshine Stars, picked up eight points out of 12 including a point in the 3-3 draw at Akwa United after clawing their way back from 1-3.Relegation-threatened Shooting Stars Sports Club (3SC) under Ogunbote in June got 10 points out of 15, losing just a game out of five to Lobi Stars while they became the first side to claim full points at the Agege Stadium in Lagos against MFM FC.Maikaba masterminded Wikki’s good show in June from the dugout as they took 13 points out of 18 in six games including a 1-0 win at Ikorodu United and a scoreless draw at Heartland. Wikki also defeated storied oppositions in Enyimba and Kano Pillars in the month under review.Dogo got among the nominees for June after Nasarawa United’s wins over Oriental teams Enyimba and FC Ifeanyiubah as well as Niger Tornadoes. But they suffered a 0-2 loss at MFM FC in between their decent run in June.The winners for both NPFL-LBA categories for June will be announced next week.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram
Everton Director of Football, Steve Walsh and Manager, Ronald Koeman, have fond words for the pacy Onyekuru whom they regard as one for the future.Onyekuru made his senior debut for Nigeria in the 3-0 friendly win over Togo earlier this month in France.Similarly, Everton is also hoping to make a formal announcement soon on the deal for Malaga’s Spain Under-21 striker Sandro Ramirez, who has also had a medical and agreed personal terms.The Premiership team will pay Â£5.2m for 21-year-old Sandro, the transfer fee release clause inserted into his contract when he left Barcelona last summer, but official confirmation has been delayed by his involvement in the European Under-21 Championship, where Spain played Italy in the semi-final last nightÂ Everton has already signed England Under-21 goalkeeper Jordan Pickford from Sunderland for Â£30m and Ajax captain Davy Klaassen in a Â£24m deal.Toffees boss Koeman and Director of Football Walsh are now expected to intensify their pursuit of Burnley’s Â£25m-rated England defender Michael Keane and Swansea City’s Iceland midfielder Gylfi Sigurdsson.The Toffees are also considering a Â£10m for Burnley striker Andre Gray.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram To go on loan at AnderlechtFemi Solaja with agency reportNigeria striker Henry Onyekuru, 20, is close to sealing a Â£7million deal with Everton.The KAS Eupen forward who scored 22 goals for the Belgian top-flight club last season, has been linked with Arsenal, West Ham United and clubs throughout Europe. Heâ€™s understood to have had a medical with Everton on Monday.Sources in England hinted yesterday that may not join the fray at Everton in the coming season as he is going to be loaned out to Anderlecht for the next 12 months to continue his development in the Belgian league.
Facebook Twitter Google+ If Syracuse’s run to the championship game of the 2013 Big East tournament was the “James Southerland Show,” its quarterfinal matchup with Pittsburgh was the second act.On college basketball’s biggest stage, the Syracuse sharpshooter carried his long-range stroke from the previous afternoon. He connected on all six of his 3-point attempts to lead the No. 19 Orange to a 62-59 triumph over No. 17 Pittsburgh at Madison Square Garden on March 14, 2013.Southerland set the Big East tournament record for made 3s without a miss as he dropped 20 points on the Panthers, and would eventually break the record for most 3s in tournament history.“When I’m shooting the ball, it’s just making sure every shot goes in and I’m really focused, making sure I help my team out as much as possible,” Southerland said after the game.In the Orange’s first game of the conference tournament, Southerland drilled 6-of-9 from 3-point territory to spearhead SU’s 12-point victory over Seton Hall.AdvertisementThis is placeholder textAnd a day later, it was more of the same.The Orange built a 25-15 lead by the 5:31 mark of the first half behind a trio of 3s from the senior forward — including two in a span of two minutes, sparking a quick 10-0 SU run.When the Panthers bit back with a 12-5 spurt, Southerland countered with his fourth and fifth triples of the game and Syracuse took a 13-point edge into the locker room.In the second half, however, Pittsburgh whittled away enough to draw within five points with six minutes left on the clock. But on SU’s next possession, Southerland cut to the right wing and knocked down a catch-and-shoot 3 off a pass from Michael Carter-Williams to push SU’s lead to eight.“It’s a great feeling,” Southerland said. “I didn’t realize I was 6-for-6 until I looked down at the paper now. I don’t think about it. I just go out and play and make sure I make every shot.”Pittsburgh still managed to climb back. Talib Zanna’s layup with 31 seconds left cut the deficit to one point, but Carter-Williams drained four foul shots in the final 27 seconds to clinch the win.Southerland’s first-half damage proved to be too much for the Panthers to overcome, and the Orange was able to close out the Big East chapter of the Syracuse-Pittsburgh rivalry with a Big East tournament victory.“We just had great ball movement,” head coach Jim Boeheim said after the game. “Got the open guys, and James just got good looks and he made them.”— Compiled by Phil D’Abbraccio, asst. copy editor, [email protected] Comments Published on January 17, 2014 at 4:12 am